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Hi all:
I am curious if anyone know about drugs in literature that are
bioequivalent with regard to parent compound but not bioequivalent as
far as active metabolite(s) of the same drug is(are) concerned.
Thanks so much.
~~~~~~~~~~~~~~~~~
Gopal Krishna, Ph.D. 2015 Galloping Hill Road, K15-2-2650
DMPK, Schering-Plough Kenilworth, NJ 07033-0539
Email: Gopal.Krishna.-a-.spcorp.com Phone: 908-740-6564, Fax: 740-2916
Maintainer: PK web page> griffin.vcu.edu/~gkrishna/PK/pk.html
~~~~~~~~~~~~~~~~~~
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Hi Gopal,
I would imagine that most narrow therapeutic drugs would have such a
feature. For
example, with Levothyroxine Sodium, it is difficult to establish bioequivalence
with the metabolite T3 as opposed to the parent compound T4.
Hope that helps.
Vatsa (Sreevatsa G. Natarajan)
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Dear Gopal,
I do not know any specific examples. In principle, if metabolite formation
and/or elimination is saturable, then such a phenomenon is possible; aspirin
would be a good example.
Sri
Sri Melethil, Ph.D.
Professor of Pharmaceutics and Medicine
University of Missouri-KC
School of Pharmacy
Room 203-B, 5005 Rockhilll Road
Kansas City, MO 64110
816-235-1794 (fax: 816-235-5190)
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