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Hello sir,
For the determination of P'kinetic studies normally blood
samples are collected from vein. Other than practical problem is there any
specific reason for collection from vein, why not from artery. Pls.. answer
my question.
koumaravelou.
deekay.aaa.md3.vsnl.net.in
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[Two replies - db]
Date: Tue, 12 Oct 1999 08:25:56 -0400
From: "Cotler, Stanley {DRUG~Nutley}"
Subject: RE: PharmPK Blood collection from vein
To: "'PharmPK.aaa.boomer.org'"
Suggest you look at an old paper J Pharm, Pharm 1980 , 32:57
Stanley C
Stanley Cotler
Department of Non-Clinical Drug Safety
Phone (973) 235-2857 Fax (973) 235-7010
E-Mail Stanley.Cotler .-a-.Roche.com
Nutley
---
From: "Michael E. Burton"
To: "'PharmPK.-at-.boomer.org'"
Subject: RE: PharmPK Blood collection from vein
Date: Tue, 12 Oct 1999 10:09:19 -0500
Importance: high
X-Priority: 1
Dear Mr. Velou:
Arterial blood collections are difficult in humans unless the artery
is cannulated which requires a surgical procedure and the cannula must be
anticoagulated. Plus, arterial sticks for individual collection hurt the
patient and require arterial compression for several minutes after the
collection to ensure no bleeding occurs. The number of samples required
for most pharmacokinetic studies would likely severely damage the artery,
occlude the artery and possible cause a loss of blood flow to the affected
area of the body. Remember the arterial side is the high pressure side of
vasculature. Arterial sampling is just impractical and too expensive
(paying the surgeon and cost of materials). Even when subclavian catheters
are in place in the right ventricle of patients (still venous blood), pulling
blood through this line can be a problem because the catheter can have an
internal clot especially with the multiple blood collections required for
pharmacokinetic studies. This would require surgical replacement. Unless
using animals, or in specialized studies, stick with the venous side just
for the practicality only.
Michael E. Burton, Pharm.D.
The University of Oklahoma College of Pharmacy
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