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Does anybody know log P (lipophilicity) of troglitazone (Rezulin)?
Charles Oo
Roche Lab Inc
Nutley NJ 07054
Charles.oo.aaa.roche.com
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Estimations based on Moriguchi (logP), Meylan (Solubility), Hayduk-Laudie
(Diffusivity), and Simulations Plus (Human Jejunal Permeability) are as
follows:
For references see: http://www.simulations-plus.com
Human Peff: 0.96 (cm/s x 10^4)
logP: 2.69
Solubility: 1.72E-02 mg/mL
Diffusivity: 0.6214 (cm^2/s x 10^5)
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)