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Hello
I am a doctorate student and I am currently developing a project regarding
the influence of protein-binding on pk-pd. I would like to get some
information of how to calculate total drug concentration when free
concentrations and binding parameters are known. Also, any other suggestion
about how to model this factor (protein-binding) on pk-pd relationship will
be greatly appreciated.
Jose Perez-Urizar
Depto. de Farmacolog=EDa y Toxicolog=EDa
CINVESTAV-IPN, Mexico
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Dear Dr Jose Perez-Urinar,
With respect to the latter, you might find this information in my
paper in J Pharmacokinet Biopharm 1996;24:45-77.
Best regards,
Johannes H. Proost
Dept. of Pharmacokinetics and Drug Delivery
University Centre for Pharmacy
Groningen, The Netherlands
tel. 31-50 363 3292
fax 31-50 363 3247
Email: j.h.proost.-at-.farm.rug.nl
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