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>---I need to measure the antiviral drug RIBAVIRIN . I would like to know
more about the drug and some information about some HPLC method to measure
it.
Marcelo Grosman
Diagnostico Bioquimico Especializado
Buenos Aires. Argentina.
E-mail : ldbe.at.cvtci.com.ar
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Try
Ribavirin and interferon alfa-2b in chronic hepatitis C: assessment of
possible pharmacokinetic and pharmacodynamic interactions.
Khakoo S; Glue P; Grellier L; et al.
Br J Clin Pharmacol 1998 Dec;46(6):563-70
Ribavirin taken for 6 months may cause
1) anemia
2) increased iron stores in liver (due to the increased loss of RBC's)
3)decreased lymphocytes in blood, 20 %
In some patients, there may be
1) increased uric acid leading to gout
2) itching of skin, 1 in 10 incidence
3) nasal stuffiness, sinus problems, ear infections, 1/10
4) fatigue, irratibility, anxiety
5) gallstones (again due to anemia and loss of RBC's)
shoaf.aaa.clinpharm.niaaa.nih.gov |Nat'l Institute on Alcohol Abuse and Alcoholism
I don't speak for NIAAA, |Unit of Pharmacokinetic Studies
That's for the PR office |
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